LIVER FUNCTION TEST
This test is designed to describe the basic liver function tests. This test includes the total protein, albumin, globulin, A/G ratio, total bilirubin, alkaline phosphatase, SGPT/ALT, SGOT/AST and Gamma-GT. If the last four terms are not inside the normal range, there may be some reasons: lack of sleeping or not sleeping well, smoker or passive smoker, and drinking alcohol for a long period of time.
- Total protein, albumin and globulin: The major serum proteins measured are albumin and globulin. Albumin is the major constituent of serum protein. High levels are seen rarely in liver disease, lower levels are seen in poor diets. Globulin is the major protein present in our blood and is the only protein that can be synthesized by our liver. When the liver is chronically damaged, the albumin level may be low. This condition tells us that the synthetic function of the liver is diminished. Malnutrition can also cause low level of albumin.
- A/G ratio (Albumin/Globulin ratio): A/G ratio is an important indicator of disease.
- Total bilirubin: Bilirubin is a major breakdown product of hemoglobin. Hemoglobin is transferred to the liver where it undergoes further metabolism in a process. High level of bilirubin will cause a disease called jaundice.
- Alkaline Phosphatase: It is an enzyme that is associated with the biliary tract. Kidney and intestinal damage may cause the alkaline phosphatase to rise.
- Alanine Aminotransferase (ALT): It is the enzyme produced within the cells of the liver. Any form of hepatic cell damage can result in an elevation in this enzyme.
- Aspartate Aminotransferase (AST): It is an enzyme which reflects damage to the hepatic cell. It may be elevated and other conditions such as heart attack.
- Gamma Glutamic Transpeptidase (GGT): It is also another type of enzyme related to liver disease. Medications commonly cause GGT to be elevated. Liver toxins such as alcohol can cause increases in the GGT.